Drafted by the San Francisco Giants in the 18th round of the 1997 MLB June Amateur Draft from St. Louis University. He played as an infielder and outfielder.

More recently, Darin Cissell has become a contributor to "Youth Baseball Midwest," specifically with a series called "Baseball 101." In this role, he discusses topics aimed at challenging clubs, coaches, parents, and players to think about the reasons behind playing baseball. He features guests to discuss various aspects of the sport, including college recruitment and the player's perspective on the recruitment process.